Role of TNF-α in Periodontal Disease & Its Implication on Systemic Health

Periodontal disease is a polymicrobial infection, characterized by gingival inflammation, pocket formation, loss of connective tissue attachment and supporting alveolar bone. Though the etiology periodontal has been established micro-organisms have implicated, pathology these inflammatory lesions attributed not only to bacterial products, that adverse effects on tissues, but also chemical mediators released host cells, as result immune reactions. Oral micro- organisms trigger endogenous pathways degradation activating cells produce release cytokines. These cytokines manifest potent pro-inflammatory catabolic activity may play key role in local amplification response well breakdown Apart from playing an important destruction, systemic elevation TNF –  levels extremely toxic hence termed “Suicide hormone”. , postulated mediate wasting during chronic infections. This review aims explore & its implication health.